TUM
Klinikum rechts der Isar Technische Universität München
Neuro-Kopf-Zentrum
Abteilung für Neuroradiologie


Forschungsgruppen und Projekte

 

Bildgebung von psychiatrischen Erkrankungen


 

Kurzbeschreibung

Die Arbeitsgruppe konzentriert sich auf die Pathophysiologie der schizophrenen Störung, der depressiven Störung und der Alzheimer Krankheit mit speziellem Fokus auf veränderte intrinsische Hirnnetzwerke. Zusätzlich untersuchen wir die Effekte von verschiedenen Emotionsregulationsstrategien auf Emotionslernen mit besonderem Schwerpunkt auf sozial-induzierte Regulationsverfahren. Dazu verwenden wir einen Strauss multimodaler Bildgebungsverfahren wie z.B. Modell-basiertes fMRI, Ruhe-fMRI, DTI, strukturelles MRI, FDG-PET, Amyloid-PET.

Leitung

Mitarbeiter

Satja Mulei Bratec;
Josef Bäuml;
Mihai Avram;
Julia Neitzel;
Georg Starke;
Teresa Bertram;
Daniel Hoffmann Ayala;
Felix Brandl

Kooperation

PD Kathrin Finke, Prof. Hermann Müller (Ludwig Maximilian Universität, Experimental Psychologie, Neuro-cognitive Psychology)

Förderung

Alzheimer Forschungsinitiative AFI;
EU Grant Marie Curie Initial Training Network (MC ITN);
CSC Chinese Scholarship Council


 

Ausgewählte Publikationen

Franzmeier N, Göttler J, Grimmer T, Drzezga A, Áraque-Caballero MA, Simon-Vermot L, Taylor ANW, Bürger K, Catak C, Janowitz D, Müller C, Duering M, Sorg C, Ewers M. Resting-State Connectivity of the Left Frontal Cortex to the Default Mode and Dorsal Attention Network Supports Reserve in Mild Cognitive Impairment. Front Aging Neurosci. 2017 Aug 7;9:264. doi: 10.3389/fnagi.2017.00264. eCollection 2017.

Pasquini L, Benson G, Grothe MJ, Utz L, Myers NE, Yakushev I, Grimmer T, Scherr M, Sorg C; Alzheimer’s Disease Neuroimaging Initiative. Individual Correspondence of Amyloid-β and Intrinsic Connectivity in the Posterior Default Mode Network Across Stages of Alzheimer's Disease. J Alzheimers Dis. 2017;58(3):763-773.

Ruiz-Rizzo AL, Bublak P, Redel P, Grimmer T, Müller HJ, Sorg C, Finke K. Simultaneous object perception deficits are related to reduced visual processing speed in amnestic mild cognitive impairment. Neurobiol Aging. 2017 Jul;55:132-142.

May ES, Tiemann L, Schmidt P, Nickel MM, Wiedemann N, Dresel C, Sorg C, Ploner M. Behavioral responses to noxious stimuli shape the perception of pain. Sci Rep. 2017 Mar 9;7:44083.

Savio A, Fünger S, Tahmasian M, Rachakonda S, Manoliu A, Sorg C, Grimmer T, Calhoun V, Drzezga A, Riedl V, Yakushev I. Resting state networks as simultaneously measured with fMRI and PET. J Nucl Med. 2017 Mar 2. pii: jnumed.116.185835.

Menegaux A, Meng C, Neitzel J, Bäuml JG, Müller HJ, Bartmann P, Wolke D, Wohlschläger AM, Finke K, Sorg C. Impaired visual short-term memory capacity is distinctively associated with structural connectivity of the posterior thalamic radiation and the splenium of the corpus callosum in preterm-born adults. Neuroimage. 2017 Apr 15;150:68-76.

Teipel SJ, Wohlert A, Metzger C, Grimmer T, Sorg C, Ewers M, Meisenzahl E, Klöppel S, Borchardt V, Grothe MJ, Walter M, Dyrba M. Multicenter stability of resting state fMRI in the detection of Alzheimer's disease and amnestic MCI. Neuroimage Clin. 2017 Jan 18;14:183-194.

Degradation in intrinsic connectivity networks across the Alzheimer's disease spectrum.

Nuttall R, Pasquini L, Scherr M, Sorg C. Degradation in intrinsic connectivity networks across the Alzheimer's disease spectrum. Alzheimers Dement (Amst). 2016 Dec 10;5:35-42. doi: 10.1016/j.dadm.2016.11.006. eCollection 2016.

Grothe MJ, Scheef L, Bäuml J, Meng C, Daamen M, Baumann N, Zimmer C, Teipel S, Bartmann P, Boecker H, Wolke D, Wohlschläger A, Sorg C. Reduced Cholinergic Basal Forebrain Integrity Links Neonatal Complications and Adult Cognitive Deficits After Premature Birth. Biol Psychiatry. 2017 Jul 15;82(2):119-126.

Teipel SJ, Grothe MJ, Metzger CD, Grimmer T, Sorg C, Ewers M, Franzmeier N, Meisenzahl E, Klöppel S, Borchardt V, Walter M, Dyrba M. Robust Detection of Impaired Resting State Functional Connectivity Networks in Alzheimer's Disease Using Elastic Net Regularized Regression. Front Aging Neurosci. 2017 Jan 4;8:318.

Mulej Bratec S, Xie X, Wang Y, Schilbach L, Zimmer C, Wohlschläger AM, Riedl V, Sorg C. Cognitive emotion regulation modulates the balance of competing influences on ventral striatal aversive prediction error signals. Neuroimage. 2017 Feb 15;147:650-657.

Ploner M, Sorg C, Gross J. Brain Rhythms of Pain. Trends Cogn Sci. 2017 Feb;21(2):100-110.

Bäuml JG, Meng C, Daamen M, Baumann N, Busch B, Bartmann P, Wolke D, Boecker H, Wohlschläger A, Sorg C, Jaekel J. The association of children's mathematic abilities with both adults' cognitive abilities and intrinsic fronto-parietal networks is altered in preterm-born individuals. Brain Struct Funct. 2017 Mar;222(2):799-812.

Peters H, Riedl V, Manoliu A, Scherr M, Schwerthöffer D, Zimmer C, Förstl H, Bäuml J, Sorg C, Koch K. Changes in extra-striatal functional connectivity in patients with schizophrenia in a psychotic episode. Br J Psychiatry. 2017 Jan;210(1):75-82.

Grothe MJ, Scheef L, Bäuml J, Meng C, Daamen M, Baumann N, Zimmer C, Teipel S, Bartmann P, Boecker H, Wolke D, Wohlschläger A, Sorg C. Reduced Cholinergic Basal Forebrain Integrity Links Neonatal Complications and Adult Cognitive Deficits After Premature Birth. Biol Psychiatry. 2017 Jul 15;82(2):119-126.

Neitzel J, Ortner M, Haupt M, Redel P, Grimmer T, Yakushev I, Drzezga A, Bublak P, Preul C, Sorg C, Finke K. Neuro-cognitive mechanisms of simultanagnosia in patients with posterior cortical atrophy. Brain. 2016 Dec;139(Pt 12):3267-3280. Epub 2016 Oct 3.

Ortner M, Pasquini L, Barat M, Alexopoulos P, Grimmer T, Förster S, Diehl-Schmid J, Kurz A, Förstl H, Zimmer C, Wohlschläger A, Sorg C, Peters H. Progressively Disrupted Intrinsic Functional Connectivity of Basolateral Amygdala in Very Early Alzheimer's Disease. Front Neurol. 2016 Sep 19;7:132. eCollection 2016.

Wohlschläger AM, Glim S, Shao J, Draheim J, Köhler L, Lourenço S, Riedl V, Sorg C. Ongoing Slow Fluctuations in V1 Impact on Visual Perception. Front Hum Neurosci. 2016 Aug 23;10:411.

Hölzel BK, Brunsch V, Gard T, Greve DN, Koch K, Sorg C, Lazar SW, Milad MR. Mindfulness-Based Stress Reduction, Fear Conditioning, and The Uncinate Fasciculus: A Pilot Study. Front Behav Neurosci. 2016 Jun 15;10:124.

Xie X, Mulej Bratec S, Schmid G, Meng C, Doll A, Wohlschläger A, Finke K, Förstl H, Zimmer C, Pekrun R, Schilbach L, Riedl V, Sorg C. How do you make me feel better? Social cognitive emotion regulation and the default mode network. Neuroimage. 2016 Jul 1;134:270-80.

Poeppl TB, Müller VI, Hoffstaedter F, Bzdok D, Laird AR, Fox PT, Langguth B, Rupprecht R, Sorg C, Riedl V, Goya-Maldonado R, Gruber O, Eickhoff SB. Imbalance in subregional connectivity of the right temporoparietal junction in major depression. Hum Brain Mapp. 2016 Aug;37(8):2931-42.

Doll A, Hölzel BK, Mulej Bratec S, Boucard CC, Xie X, Wohlschläger AM, Sorg C. Mindful attention to breath regulates emotions via increased amygdala-prefrontal cortex connectivity. Neuroimage. 2016 Jul 1;134:305-13.

Peters H, Shao J, Scherr M, Schwerthöffer D, Zimmer C, Förstl H, Bäuml J, Wohlschläger A, Riedl V, Koch K, Sorg C. More Consistently Altered Connectivity Patterns for Cerebellum and Medial Temporal Lobes than for Amygdala and Striatum in Schizophrenia. Front Hum Neurosci. 2016 Feb 17;10:55.

Teipel S, Grothe MJ, Zhou J, Sepulcre J, Dyrba M, Sorg C, Babiloni C. Measuring Cortical Connectivity in Alzheimer's Disease as a Brain Neural Network Pathology: Toward Clinical Applications. J Int Neuropsychol Soc. 2016 Feb;22(2):138-63.

Pasquini L, Scherr M, Tahmasian M, Myers NE, Ortner M, Kurz A, Förstl H, Zimmer C, Grimmer T, Akhrif A, Wohlschläger AM, Riedl V, Sorg C. Increased Intrinsic Activity of Medial-Temporal Lobe Subregions is Associated with Decreased Cortical Thickness of Medial-Parietal Areas in Patients with Alzheimer's Disease Dementia. J Alzheimers Dis. 2016;51(1):313-26.

Riedl V, Utz L, Castrillón G, Grimmer T, Rauschecker JP, Ploner M, Friston KJ, Drzezga A, Sorg C. Metabolic connectivity mapping reveals effective connectivity in the resting human brain. Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):428-33.

Bludau S, Bzdok D, Gruber O, Kohn N, Riedl V, Sorg C, Palomero-Gallagher N, Müller VI, Hoffstaedter F, Amunts K, Eickhoff SB. Medial Prefrontal Aberrations in Major Depressive Disorder Revealed by Cytoarchitectonically Informed Voxel-Based Morphometry. Am J Psychiatry. 2016 Mar 1;173(3):291-8.

Tahmasian M, Shao J, Meng C, Grimmer T, Diehl-Schmid J, Yousefi BH, Förster S, Riedl V, Drzezga A, Sorg C. Based on the Network Degeneration Hypothesis: Separating Individual Patients with Different Neurodegenerative Syndromes in a Preliminary Hybrid PET/MR Study. J Nucl Med. 2016 Mar;57(3):410-5.

Grimmer T, Wutz C, Alexopoulos P, Drzezga A, Förster S, Förstl H, Goldhardt O, Ortner M, Sorg C, Kurz A. Visual Versus Fully Automated Analyses of 18F-FDG and Amyloid PET for Prediction of Dementia Due to Alzheimer Disease in Mild Cognitive Impairment. J Nucl Med. 2016 Feb;57(2):204-7.

Jurcoane A, Daamen M, Scheef L, Bäuml JG, Meng C, Wohlschläger AM, Sorg C, Busch B, Baumann N, Wolke D, Bartmann P, Hattingen E, Boecker H. White matter alterations of the corticospinal tract in adults born very preterm and/or with very low birth weight. Hum Brain Mapp. 2016 Jan;37(1):289-99.

Meng C, Bäuml JG, Daamen M, Jaekel J, Neitzel J, Scheef L, Busch B, Baumann N, Boecker H, Zimmer C, Bartmann P, Wolke D, Wohlschläger AM, Sorg C. Extensive and interrelated subcortical white and gray matter alterations in preterm-born adults. Brain Struct Funct. 2016 May;221(4):2109-21.

Boucard CC, Rauschecker JP, Neufang S, Berthele A, Doll A, Manoliu A, Riedl V, Sorg C, Wohlschläger A, Mühlau M. Visual imagery and functional connectivity in blindness: a single-case study. Brain Struct Funct. 2016 May;221(4):2367-74.

Bäuml JG, Meng C, Daamen M, Baumann N, Busch B, Bartmann P, Wolke D, Boecker H, Wohlschläger A, Sorg C, Jaekel J. The association of children's mathematic abilities with both adults' cognitive abilities and intrinsic fronto-parietal networks is altered in preterm-born individuals. Brain Struct Funct. 2016 Jun 13

Sorg C, Göttler J, Zimmer C. Imaging Neurodegeneration: Steps Toward Brain Network-Based Pathophysiology and Its Potential for Multi-modal Imaging Diagnostics. Clin Neuroradiol. 2015 Oct;25 Suppl 2:177-81.

Pasquini L, Scherr M, Tahmasian M, Meng C, Myers NE, Ortner M, Mühlau M, Kurz A, Förstl H, Zimmer C, Grimmer T, Wohlschläger AM, Riedl V, Sorg C. Link between hippocampus' raised local and eased global intrinsic connectivity in AD. Alzheimers Dement. 2015 May

Sorg C, Grothe MJ. The complex link between amyloid and neuronal dysfunction in Alzheimer's disease. Brain. 2015 Dec

Meng C, Brandl F, Tahmasian M, Shao J, Manoliu A, Scherr M, Schwerthöffer D, Bäuml J, Förstl H, Zimmer C, Wohlschläger AM, Riedl V, Sorg C. Aberrant topology of striatum’s connectivity is associated with the number of episodes in depression. Brain 2014.

Myers N, Pasquini L, Göttler J, Grimmer T, Koch K, Ortner M, Neitzel J, Mühlau M, Förster S, Kurz A, Förstl H, Zimmer C, Wohlschläger AM, Riedl V, Drzezga A, Sorg C. Within-patient correspondence of amyloid-β and intrinsic network connectivity in Alzheimer’s disease. Brain 2014.

Pasquini L, Scherr M, Tahmasian M, Meng C, Myers NE, Ortner M, Mühlau M, Kurz A, Förstl H, Zimmer C, Grimmer T, Wohlschläger AM, Riedl V, Sorg C. Link between hippocampus’ raised local and eased global intrinsic connectivity in AD. Alzheimer’s and Dementia 2014

Sorg, C, Manoliu, A., Neufang, S., Myers, N., Peters, H., Schwerthoffer, D., et al. Increased intrinsic brain activity in the striatum reflects symptom dimensions in schizophrenia. Schizophr. Bull. 2013; 39, 387–395.

Sorg, C., Myers, N., Redel, P., Bublak, P., Riedl, V., Manoliu, A., Perneczky, R., Grimmer, T., Kurz, A., Förstl, H., et al. Asymmetric Loss of Parietal Activity Causes Spatial Bias in Prodromal and Mild Alzheimer's Disease. Biological Psychiatry. 2012; 71, 798–804.

Sorg, C., Riedl, V., Mühlau, M., Calhoun, V.D., Eichele, T., Laer, L., Drzezga, A., Förstl, H., Kurz, A., Zimmer, C., et al. (2007). Selective changes of resting- state networks in individuals at risk for Alzheimer's disease. PNAS: 2007; 104, 18760–18765.


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