Klinikum rechts der Isar Technische Universität München
Neuro-Kopf-Zentrum
Abteilung für Neuroradiologie
Forschungsgruppen und Projekte
Neuropsychiatry and Neuroimaging Lab
Kurzbeschreibung
Das Neuropsychiatry and Neuroimaging Lab untersucht makroskopische Hirnsystems in gesunden Erwachsenen and Patienten mittels multi-modalen Bildgebungsverfahren. Wir konzentrieren uns dabei auf Hirnentwicklungsstörungen (v.a. Schizophrenie und Frühgeburtlichkeit) und neurodegenerative Erkrankungen (v.a. Alzheimer Krankheit). Unser zentrale Bildgebungsmethode ist die funktionelle MRT erweitert um EEG, strukturelles und Perfusion-basiertes MRT und verschiedene PET Methoden.
Leitende Forschungsfragen sind: wie sehen Schwankungen in der Blutoxygenierung genau aus (BOLD-Signal als Hauptsignal der fMRT), wie werden sie erzeugt d.h. wie hängen sie mit neuronalen Oszillationen und Blutperfusion zusammen, wie werden sie durch Neuromodulatoren wie z.B. Dopamin verändert, und schließlich wie sind diese Vorgänge in einzelnen Patienten verändert.
Summary
The Neuropsychiatry and Neuroimaging Lab studies large-scale brain systems in healthy humans and neuropsychiatric patients by the use of multi-modal imaging techniques. Main focus is on neurodevelopmental (schizophrenia and premature birth) and neurodegenerative disorders (Alzheimer’s disease). Key method is functional MRI extended by EEG, perfusion-based MRI, and PET.
We are interested how blood oxygenation fluctuates – i.e. the main functional MRI signal -, how these fluctuations link with both neural oscillations and blood perfusion, how they spread across the cortex, how they are altered by neuromodulators such as dopamine, and how these processes are impaired in neurodevelopmental and neurodegenerative disorders. Therefore, we use simultaneous in-vivo imaging of ongoing brain processes at rest in humans together with a modelling approach on processes of interest.
Leitung
Mitarbeiter
Satja Mulei Bratec;
Juliana Zimmermann;
Felix Brandl;
Mihai Avram;
Franziska Knolle;
Aurore Menegaux;
Teresa Bertram;
Sebastian Schneider;
Rachel Nuttall;
James Dowsett;
Josef Bäuml;
Dennis Hedderich
Kooperation
- Dieter Wolke (Warwick, Warwick University Psychology);
- Kathrin Finke (Jena, Jena University Neurology);
- Hermann Müller (München, LMU Psychology);
- Michel Grothe (DZNE Rostock);
- PD Kathrin Finke, Prof. Hermann Müller (Ludwig Maximilian Universität, Experimental Psychologie, Neuro-cognitive Psychology)
Förderung
DFG;
BMBF;
EU;
AFI
Ausgewählte Publikationen
Avram M, Brandl F, Cabello J, Leucht C, Scherr M, Mustafa M, Leucht S, Ziegler S, Sorg C. Reduced striatal dopamine synthesis capacity in patients with schizophrenia during remission of positive symptoms. Brain. 2019 Jun 1;142(6):1813-1826
Hedderich DM, Bäuml JG, Berndt MT, Menegaux A, Scheef L, Daamen M, Zimmer C, Bartmann P, Boecker H, Wolke D, Gaser C, Sorg C. Aberrant gyrification contributes to the link between gestational age and adult IQ after premature birth. Brain. 2019 May 1;142(5):1255-1269
Scherr M, Utz L, Tahmasian M, Pasquini L, Grothe MJ, Rauschecker JP, Grimmer T, Drzezga A, Sorg C, Riedl V. Effective connectivity in the default mode network is distinctively disrupted in Alzheimer's disease-A simultaneous resting-state FDG-PET/fMRI study.Hum Brain Mapp. 2019 Jan 30
Brandl F, Avram M, Weise B, Shang J, Simões B, Bertram T, Hoffmann Ayala D, Penzel N, Gürsel DA, Bäuml J, Wohlschläger AM, Vukadinovic Z, Koutsouleris N, Leucht S, Sorg C. Specific Substantial Dysconnectivity in Schizophrenia: A Transdiagnostic Multimodal Meta-analysis of Resting-State Functional and Structural Magnetic Resonance Imaging Studies.Biol Psychiatry. 2019 Apr 1;85(7):573-583
Avram M, Brandl F, Bäuml J, Sorg C. Cortico-thalamic hypo- and hyperconnectivity extend consistently to basal ganglia in schizophrenia. Neuropsychopharmacology. 2018 Oct;43(11):2239-2248
Göttler J, Preibisch C, Riederer I, Pasquini L, Alexopoulos P, Bohn KP, Yakushev I, Beller E, Kaczmarz S, Zimmer C, Grimmer T, Drzezga A, Sorg C. Reduced blood oxygenation level dependent connectivity is related to hypoperfusion in Alzheimer's disease. J Cereb Blood Flow Metab. 2019 Jul;39(7):1314-1325
Pasquini L, Benson G, Grothe MJ, Utz L, Myers NE, Yakushev I, Grimmer T, Scherr M, Sorg C; Alzheimer’s Disease Neuroimaging Initiative. Individual Correspondence of Amyloid-β and Intrinsic Connectivity in the Posterior Default Mode Network Across Stages of Alzheimer's Disease. J Alzheimers Dis. 2017;58(3):763-773
Menegaux A, Meng C, Neitzel J, Bäuml JG, Müller HJ, Bartmann P, Wolke D, Wohlschläger AM, Finke K, Sorg C. Impaired visual short-term memory capacity is distinctively associated with structural connectivity of the posterior thalamic radiation and the splenium of the corpus callosum in preterm-born adults. Neuroimage. 2017 Apr 15;150:68-76
Grothe MJ, Scheef L, Bäuml J, Meng C, Daamen M, Baumann N, Zimmer C, Teipel S, Bartmann P, Boecker H, Wolke D, Wohlschläger A, Sorg C. Reduced Cholinergic Basal Forebrain Integrity Links Neonatal Complications and Adult Cognitive Deficits After Premature Birth. Biol Psychiatry. 2017 Jul 15;82(2):119-126
Riedl V, Utz L, Castrillón G, Grimmer T, Rauschecker JP, Ploner M, Friston KJ, Drzezga A, Sorg C. Metabolic connectivity mapping reveals effective connectivity in the resting human brain. Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):428-33
Sorg C, Grothe MJ. The complex link between amyloid and neuronal dysfunction in Alzheimer's disease. Brain. 2015 Dec;138(Pt 12):3472-5.
Bäuml JG, Daamen M, Meng C, Neitzel J, Scheef L, Jaekel J, Busch B, Baumann N, Bartmann P, Wolke D, Boecker H, Wohlschläger AM, Sorg C. Correspondence Between Aberrant Intrinsic Network Connectivity and Gray-Matter Volume in the Ventral Brain of Preterm Born Adults. Cereb Cortex. 2015 Nov;25(11):4135-45
Myers N, Pasquini L, Göttler J, Grimmer T, Koch K, Ortner M, Neitzel J, Mühlau M, Förster S, Kurz A, Förstl H, Zimmer C, Wohlschläger AM, Riedl V, Drzezga A, Sorg C. Within-patient correspondence of amyloid-β and intrinsic network connectivity in Alzheimer's disease. Brain. 2014 Jul;137(Pt 7):2052-64
Meng C, Brandl F, Tahmasian M, Shao J, Manoliu A, Scherr M, Schwerthöffer D, Bäuml J, Förstl H, Zimmer C, Wohlschläger AM, Riedl V, Sorg C. Aberrant topology of striatum's connectivity is associated with the number of episodes in depression. Brain. 2014 Feb;137(Pt 2):598-609
Manoliu A, Riedl V, Zherdin A, Mühlau M, Schwerthöffer D, Scherr M, Peters H, Zimmer C, Förstl H, Bäuml J, Wohlschläger AM, Sorg C. Aberrant dependence of default mode/central executive network interactions on anterior insular salience network activity in schizophrenia. Schizophr Bull. 2014 Mar;40(2):428-37
Sorg C, Manoliu A, Neufang S, Myers N, Peters H, Schwerthöffer D, Scherr M, Mühlau M, Zimmer C, Drzezga A, Förstl H, Bäuml J, Eichele T, Wohlschläger AM, Riedl V. Increased intrinsic brain activity in the striatum reflects symptom dimensions in schizophrenia. Schizophr Bull. 2013 Mar;39(2):387-95
Sorg C, Riedl V, Mühlau M, Calhoun VD, Eichele T, Läer L, Drzezga A, Förstl H, Kurz A, Zimmer C, Wohlschläger AM. Selective changes of resting-state networks in individuals at risk for Alzheimer's disease. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18760-5