TUM
Klinikum rechts der Isar Technische Universität München
Neuro-Kopf-Zentrum
Abteilung für Neuroradiologie


Forschungsgruppen und Projekte

 

Hirnstruktur und Hirnfunktion bei neuropsychiatrischen Erkrankungen


 

Kurzbeschreibung

Using MRI, fMRI and DTI we investigate neural alterations in different neuropsychiatric disorders with a strong focus on obsessive-compulsive disorder. We use univariate, multivariate and connectivity analyses to characterize the functional and structural changes in order to develop a better understanding of their relevance for the development and manifestation of specific symptoms or symptom dimensions.

Leitung

Mitarbeiter

M. Emch;
M. Mora;
Q. Wu;
B. Bremer;
A. Torske

Kooperation

Dr. Götz Berberich, Psychosomatische Klinik Windach
Dr. Victor Spoormaker, Max-Planck-Institut für Psychiatrie

Förderung

DFG KO 3744/7-1 DFG KO 3744/8-1
DFG KO 3744/7-1 DFG KO 3744/7-1
BMBF Kompetenzcluster „enable“


 

Ausgewählte Publikationen

Alves-Pinto A, Rus OG, Reess TJ, Wohlschläger A, Wagner G, Berberich G, Koch K. Altered reward-related effective connectivity in obsessive-compulsive disorder: an fMRI study. Journal of Psychiatry and Neuroscience. 2018; 44, 1-12

Reess TJ, Rus OG, Gürsel DA, Schmitz-Koep B, Wagner G, Berberich G, Koch K. Network-based decoupling of local gyrification in obsessive-compulsive disorder. Human Brain Mapping. 2018; 39, 3216-3226

Gürsel DA, Avram M, Sorg C, Brandl F, Koch K. Frontoparietal areas link impairments of large scale intrinsic brain networks with aberrant fronto-striatal interactions in OCD: a meta-analysis of resting-state functional connectivity. Neuroscience & Biobehavioral Reviews. 2018; 87, 151-160

Reess TJ, Rus OG, Gürsel DA, Schmitz-Koep B, Wagner G, Berberich G, Koch K. Association between hippocampus volume and symptom profiles in obsessive-compulsive disorder. Neuroimage Clin. 2017; 17, 474-480.

Rus OG, Reess TJ, Wagner G, Zaudig M, Zimmer C, Koch K. Structural alterations in patients with obsessive-compulsive disorder: a surface-based analysis of cortical volume, surface area and thickness. J Psychiatry Neurosci. 2017; 42, 395-403.

Peters H, Riedl V, Manoliu A, Scherr M, Schwerthöffer D, Zimmer C, Förstl H, Bäuml J, Sorg C, Koch K. Changes in extra-striatal functional connectivity in patients with schizophrenia in a psychotic episode. Br J Psychiatry. 2016 Feb 18. pii: bjp.bp.114.151928.

Reess TJ, Rus OG, Schmidt R, de Reus MA, Zaudig M, Wagner G, Zimmer C, van den Heuvel MP, Koch K. Connectomics-based structural network alterations in obsessive-compulsive disorder. Transl Psychiatry. 2016; 6(9):e882.

Rus OA, Reess TR, Wagner G, Zaudig M, Zimmer C, Koch K. Hypogyrification in obsessive-compulsive disorder. Psychological Medicine. 2017; 47, 1053-1061.

Koch K, Reess TJ, Rus OG, Zimmer C. Extensive learning is associated with gray matter changes in the right hippocampus. Neuroimage. 2016; 125, 627-632.

Koch K, Reeß TJ, Rus OG, Zimmer C, Zaudig M. Diffusion tensor imaging (DTI) studies in patients with obsessive-compulsive disorder (OCD): A review. J Psychiatr Res. 2014; 54, 26-35.

Koch K, Schultz CC, Wagner G, Schachtzabel C, Reichenbach JR, Sauer H, Schlösser R. Disrupted white matter connectivity is associated with reduced cortical thickness in the cingulate cortex in schizophrenia. Cortex. 2013; 49, 722-729.


Forschungsgruppen und Projekte Doktoranden, PhD, Diplomanden Auftragsforschung/Industriestudien Publikationen Postergalerie Auszeichnungen Habilitationen