TUM
Klinikum rechts der Isar Technische Universität München
Neuro-Kopf-Zentrum
Abteilung für Neuroradiologie


Forschungsgruppen und Projekte

 

Individualized treatment planning in chronic back pain patients by advanced imaging and multi-parametric biomechanical models (iBack)


 

Background:

Chronic back pain is a major burden and source of disability worldwide. It is primarily attributed to biomechanical factors, but may include a neuropathic component. In elderly patients, osteoporosis complicates the determination of the source of the pain. Surgery is often required to treat instability-related pain and to restore the balance of the spine. However, when and how to perform surgery remains a highly subjective decision based on the surgeon’s experience.
We recently started to establish objective, image-based criteria for surgery outcome prediction. As an example, we were able to develop tools for routine density and fracture assessment and demonstrate that screw loosening occurs in >85% of patients with bone mineral density <92 mg/ccm. This directly influences the surgical approach in all spine surgery patients at our institution. Additionally, we improved the prediction of bone strength by advanced image post processing such as scaling indices, finite element and finite cell models.

Objectives:

The objective of iBack is to break new ground in individualized therapy planning in back pain patients based on novel in-vivo imaging and image post processing. We will improve in-vivo imaging and image analysis to compute individualized biomechanical models that allow personalized treatment planning and outcome prediction after spine surgery or conservative treatment.
The main objectives of iBack are: (1) improving computed tomography (CT) and magnetic resonance imaging (MRI) of the spine; (2) combining sagittal balance radiographs, CT and MRI of the spine in one biomechanical multi-body simulation (MBS); (3) creating a statistical model that includes both clinical and biomechanical information to reveal interactions between the two and to predict individual treatment success probability.

The results of iBack will help to better understand instability-related pain and develop personalized surgical strategies which will have major impacts on patients.

Principal Investigator

PD Dr. J. S. Kirschke

Project Members

PD Dr. med. Thomas Baum;
Dr. med. Elisabeth Klupp;
Dr. med. Dipl.-Ing. Maximilian Löffler;
Dr. Dr. med. Nico Sollmann, Nico, B.A.;
Anjany Sekuboyina, PhD Student;
Amir Bayat, PhD Student;
Tanja Lerchl, PhD Student

Collaborators

Prof. B. Menze (Informatics, TUM);
Dr. D. Karampinos, Dr. P. Noël (Radiology, TUM);
E. Shiban, Y. Ryang (Neurochirurgie), S. Karupppasamy (Singapur);
Prof. E. Rank (Geo and Civil Engeneering, TUM);
Prof. F. Pfeiffer (Biophysics, TUM)

Open Positions

PhD Student in Computer Science

Funding

ERC-StG iBack


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