Klinikum rechts der Isar Technische Universität München
Abteilung für Neuroradiologie

Forschungsgruppen und Projekte


Quantitative Imaging and Neuromodulation in Migraine



Migraine is frequently related to muscular pain of the neck and shoulder region and alterations of skeletal musculature, particularly affecting the trapezius muscles. We develop novel approaches to image such alterations by magnetic resonance imaging (MRI), and aim to treat migraine-related muscular pain of the neck and shoulder region by targeted neuromodulation. Our goal is to provide a better understanding of the trigemino-cervical complex (TCC) that contributes to the development and maintenance of migraine, and to integrate advanced diagnostics by MRI into clinical applications.


  • Acquisition of high-resolution MRI to study skeletal musculature in patients with migraine.
  • Neuromodulatory stimulation of trapezius muscles to alleviate migraine-related muscular pain and headache.
  • Implementation of multi-sequence MRI to detect muscular alterations subsequent to neuromodulatory treatment.
  • Understanding pathophysiological mechanisms of migraine by functional and perfusion MRI.

Grant Support

  • Dr.-Ing. Leonhard Lorenz Foundation
  • German Migraine and Headache Society (DMKG)





Corinna Börner, M.Sc.;
Paul Schandelmaier;
Severin Schramm;
Miriam Reichert


  • Prof. Dr. F. Heinen, Dr. M. V. Bonfert, PD Dr. Dipl.-Psych. M. N. Landgraf (iSPZ Hauner, LMU)
  • Prof. Dr. D. C. Karampinos, D. Weidlich (Body Magnetic Resonance Research, TUM)
  • PD Dr. C. Preibisch, S. Kaczmarz, (Neuro MR Munich, TUM)
  • Prof. Dr. S. M. Krieg (Neurosurgery, TUM)
  • Prof. Dr. Dr. T. R. Tölle (Neurology, TUM)
  • Prof. Dr. M. Beer (Radiology, Ulm University)


Selected Publications

Sollmann N*, Trepte-Freisleder F*, Albers L, Jung NH, Mall V, Meyer B, Heinen F, Krieg SM*, Landgraf MN*. Magnetic stimulation of the upper trapezius muscles in patients with migraine - A pilot study. Eur J Paediatr Neurol. 2016 Nov;20(6):888-897.

Sollmann N, Mathonia N, Weidlich D, Bonfert M, Schroeder SA, Badura KA, Renner T, Trepte-Freisleder F, Ganter C, Krieg SM, Zimmer C, Rummeny EJ, Karampinos DC, Baum T, Landgraf MN, Heinen F. Quantitative magnetic resonance imaging of the upper trapezius muscles - assessment of myofascial trigger points in patients with migraine. J Headache Pain. 2019 Jan 18;20(1):8.

Renner T*, Sollmann N*, Trepte-Freisleder F, Albers L, Mathonia NM, Bonfert MV, König H, Klose B, Krieg SM, Heinen F, Gerstl L*, Landgraf MN*. Repetitive Peripheral Magnetic Stimulation (rPMS) in Subjects With Migraine-Setup Presentation and Effects on Skeletal Musculature. Front Neurol. 2019 Jul 16;10:738.

Renner T*, Sollmann N*, Heinen F, Albers L, Trepte-Freisleder F, Klose B, König H, Krieg SM, Bonfert MV*, Landgraf MN*. Alleviation of migraine symptoms by application of repetitive peripheral magnetic stimulation to myofascial trigger points of neck and shoulder muscles - A randomized trial. Sci Rep. 2020 Apr 6;10(1):5954.

Landgraf MN, König H, Hannibal I, Langhagen T, Bonfert MV, Klose B, Rahmsdorf B, Giese RM, Straube A, von Kries R, Albers L, Ebinger F, Ertl-Wagner B, Kammer B, Koerte I, Sollmann N, Krieg S, Heinen F. Migraine in children and adolescents-brain and muscle? : Another example of why children are not small adults. Nervenarzt. 2017 Dec;88(12):1402-1410.

Bonfert MV, Börner C, Gerstl L, Hannibal I, Mathonia N, Huß K, Rahmsdorf B, Kainz C, Klose B, Koenig H, Urban G, Schandelmaier P, Renner T, Albers L, Krieg SM, Sollmann N, Heinen F, Landgraf MN. Migraine in childhood and adolescence-neurostimulation as a future innovative approach in terms of a multimodal treatment regimen. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2020 Jul;63(7):872-880.

Sollmann N*, Schandelmaier P*, Weidlich D, Börner C, Urban G, Lang M, Zimmer C, Karampinos DC, Landgraf MN, Heinen F, Baum T*, Bonfert MV*. Patients with episodic migraine show increased T2 values of the trapezius muscles – An investigation by quantitative high-resolution magnetic resonance imaging. Cephalalgia. 2021.

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