Klinikum rechts der Isar Technische Universität München
Neuro-Kopf-Zentrum
Abteilung für Neuroradiologie
Forschungsgruppen und Projekte
Neuroenergetics of the human brain
Kurzbeschreibung
The human brain consumes around 20% of the energy produced by the body. While neuroscience research has immensely progressed in understanding the micro- and macroscopic architecture of the brain, the reason for its high energy demands is still a mystery. In my research group, we study how energy metabolism drives neural signaling and whether it is altered in neuropsychiatric disorders. At TUM, I have established simultaneous measurements of glucose, oxygen and neurotransmitter metabolism in the human brain combining quantitative PET, calibrated fMRI and edited MRS on an integrated PET/MR-scanner. We also use TMS to non-invasively modulate human brain activity.
Please check my webpage for current projects and open positions via: valentinriedl.de
Leitung
Förderung
- VolkswagenStiftung "Course of Change" (2019-2020);
- ERC starting grant "SUGARCODING" (2018-2023, ID: 759659);
- Deutsche Forschungsgemeinschaft (2015-2019, ID: 273427765)
Ausgewählte Publikationen
Castrillon G, Sollmann N, Kurcyus K, Razi A, Krieg SM, Riedl V The physiological effects of noninvasive brain stimulation fundamentally differ across the human cortex. Science Advances. 2020 Jan 31. doi: 10.1126/sciadv.aay2739
Scherr M, Utz L, Tahmasian M, Pasquini L, Grothe MJ, Rauschecker JP, Grimmer T, Drzezga A, Sorg C, Riedl V Effective connectivity in the default mode network is distinctively disrupted in Alzheimer's disease-A simultaneous resting-state FDG-PET/fMRI study. Hum Brain Mapp. 2019 Jan 30. doi: 10.1002/hbm.24517
Kurcyus K, Annac E, Hanning NM, Harris AD, Oeltzschner G, Edden R, Riedl V Opposite Dynamics of GABA and Glutamate Levels in the Occipital Cortex during Visual Processing. J Neurosci. 2018 Nov. doi: 10.1523/JNEUROSCI
Riedl V, Utz L, Castrillón G, Grimmer T, Rauschecker JP, Ploner M, Friston KJ, Drzezga A, Sorg C. Metabolic connectivity mapping reveals effective connectivity in the resting human brain. Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):428-33.
Riedl V, Bienkowska K, Strobel C, Tahmasian M, Grimmer T, Förster S, Friston KJ, Sorg C, Drzezga A. Local Activity Determines Functional Connectivity in the Resting Human Brain: A Simultaneous FDG-PET/fMRI Study. J Neurosci. 2014 Apr 30;34(18):6260-6.